TABLE 2.
Incidence rates (IR) per 1000 person-months and incidence rate ratios (IRR) of injuries during the diagnostic period compared to the prediagnostic period in 59,329 patients with cirrhosis, 1997–2019 in Sweden
| Prediagnostic period | Diagnostic period | |||||
|---|---|---|---|---|---|---|
| No. injuries | IR | No. injuries | IR | IRR (95% CI) | p | |
| Total sample | ||||||
| All patients with cirrhosis | 975 | 2.8 | 3,610 | 11.6 | 8.1 (7.5–8.7) | <0.001 |
| Compensated cirrhosis | 473 | 3.4 | 1,933 | 15.1 | 8.9 (8.1–9.9) | <0.001 |
| Alcohol-associated cirrhosis | 306 | 4.3 | 1,144 | 17.7 | 7.9 (6.9–9.0) | <0.001 |
| Compensated cirrhosis due to other etiologies | 167 | 2.5 | 789 | 12.6 | 11.0 (9.4–13.1) | <0.001 |
| Decompensated cirrhosis | 502 | 2.4 | 1,677 | 9.1 | 7.0 (6.1–7.7) | <0.001 |
| Bleeding esophageal varices | 67 | 2.6 | 224 | 9.6 | 7.3 (5.5–10.1) | <0.001 |
| Ascites | 374 | 2.2 | 1,288 | 8.6 | 7.1 (6.3–8.1) | <0.001 |
| By demographics and comorbidities | ||||||
| Age at cirrhosis diagnosis (y) | ||||||
| ≤55 | 411 | 3.2 | 1200 | 10.6 | 5.7 (5.1–6.5) | <0.001 |
| 56–65 | 225 | 2.7 | 800 | 10.6 | 7.6 (6.5–8.9) | <0.001 |
| 66–75 | 186 | 2.2 | 845 | 11.2 | 10.4 (8.7–12.3) | <0.001 |
| ≥76 | 153 | 2.7 | 765 | 15.9 | 12.2 (10.1–14.7) | <0.001 |
| Sex | ||||||
| Men | 550 | 2.7 | 2141 | 11.9 | 8.7 (7.8–9.6) | <0.001 |
| Women | 425 | 2.8 | 1469 | 11.0 | 7.2 (6.4–8.1) | <0.001 |
| Education (y) | ||||||
| ≤9 | 376 | 2.9 | 1502 | 13.1 | 8.7 (7.7–9.8) | <0.001 |
| >9 | 572 | 2.7 | 1985 | 10.6 | 7.4 (6.7–8.3) | <0.001 |
| Unknown | 27 | 2.3 | 123 | 12.3 | 9.5 (6.1–14.7) | <0.001 |
| Cohabitation status | ||||||
| Yes | 505 | 2.7 | 1835 | 10.7 | 7.8 (7.0–8.7) | <0.001 |
| No | 189 | 3.1 | 784 | 14.5 | 9.8 (8.2–11.8) | <0.001 |
| Unknown | 281 | 2.7 | 991 | 11.4 | 7.3 (6.3–8.4) | <0.001 |
| Calendar year of cirrhosis diagnosis | ||||||
| 1997–2000 | 148 | 3.6 | 347 | 9.5 | 3.9 (3.2–4.9) | <0.001 |
| 2001–2010 | 320 | 2.6 | 1137 | 10.4 | 7.4 (6.4–8.4) | <0.001 |
| 2011–2019 | 507 | 2.7 | 2126 | 12.8 | 9.8 (8.8–10.9) | <0.001 |
| Diabetes | ||||||
| Yes | 69 | 4.2 | 223 | 15.9 | 7.2 (5.3–9.7) | <0.001 |
| No | 906 | 2.7 | 3387 | 11.4 | 8.1 (7.5–8.7) | <0.001 |
| Cardiovascular disease | ||||||
| Yes | 175 | 3.6 | 597 | 14.0 | 7.2 (5.9–8.6) | <0.001 |
| No | 800 | 2.6 | 3–013 | 11.1 | 8.2 (7.5–8.9) | <0.001 |
| Psychological disorder | ||||||
| Yes | 456 | 5.8 | 1194 | 16.8 | 4.9 (4.4–5.5) | <0.001 |
| No | 519 | 1.9 | 2416 | 10.0 | 10.9 (9.8–12.1) | <0.001 |
| HCC | ||||||
| Yes | 1 | 1.7 | 5 | 10.9 | 9.4 (1.1–83.1) | 0.045 |
| No | 974 | 2.8 | 3605 | 11.6 | 8.0 (7.4–8.6) | <0.001 |
| Dementia | ||||||
| Yes | 12 | 9.4 | 25 | 23.7 | 2.5 (1.2–5.4) | 0.015 |
| No | 963 | 2.7 | 3,585 | 11.5 | 8.1 (7.5–8.7) | <0.001 |