Table 1.

Previously reported cases of sintilimab-induced cutaneous adverse events.

	Characteristics	Disease	Therapy regimen	Time to Onset	Cutaneous adverse evevts	Interventions	Stop/restart sintilimab	Outcome
1[5]	55 M	Lung adenocarcinoma	Sintilimab, pemetrexed and carboplatin	44 d after the first cycle	Dermatitis bullosa	Piperacllin-tazobactam, fusidic acid cream, cetirizine and prednisone	Stop	Dead
2[6]	64 M	Cancer of the esophagogastric	Sintilimab	5 d after the first cycle	Purpura-like cutaneous vasculitis	Methylprednisolone and diphenhydramine	Stop	Survived
3[7]	72 M	Cancer, hepatopulmonary metastases	Sintilimab, pacllitaxel, liposome and carboplatin	23 d after the first cycle	Toxic epodermal necrolysis	Methylprednisolone sodium cuccinate injection and prednisone acetate tablets	Stop	Survived
4[8]	55 M	Lymphoma	Sintilimab, gemcitabine and oxaliplatin	11 d after the first cycle	Toxic epodermal necrolysis	Oral cetirizine, methylprednisolone, immunoglobulin, piperacillin sodium-tazobactam and parenteral nutrition	Stop	Survived
5[9]	72 F	Gallbladder carcinoma	Sintilimab, anlotinib	2 wk after the first cycle	Toxic epodermal necrolysis	Methylprednisolone, immunoglobulin, albumin, encapsulation, tapering of glucocorticoid and oral nystatin.	Stop	Survived
6[10]	67 M	Advanced lung squamous carcinoma	Sintilimab, albumin paclitaxel and cisplatin	32 d after the first cycle	Eczema dermatitis	Methylprednisolone and TCM (Xiaofeng powder)	Stop	Survived
7[11]	59 M	Squamous cell-lung carcinoma	Sintilimab and conventional chemotherapy	11 d after the first cycle of postoperative stilinimab therapy	Toxic epidermal necrolysis	Intravenous methylprednisolone, prednisone and Levofloxacin	Stop	Survived
8[12]	80s M	Thymic carcinoma	Sintilimab	1 wk after the first cycle	Toxic epidermal necrolysis	Intravenous methylprednisolone, followed by oral prednisone	Stop	Died
9[13]	24 M	Renal cell carcinoma	Sintilimab and axitinib	About 2 yr after the first cycle	Bullous Pemphigoid	Methylprednisolone, minocycline and nicotinamide	Stop	Survived
10[14]	27 F	Undifferentiated nonkeratinizing carcinoma of the nasopharynx	Sintilimab	After the 4th cycle of Sintilimab	Stevens-Johnson syndrome/Toxic epidermal necrolysis	Methylprednisolone, imipenem and immunoglobulin	Not mentioned	Not mentioned
11[15]	70 M	Colorectal cancer, liver metastase	Sitilimab	5 mo after the first cycle	Bullous pemphigoid	Oral methylprednisolone	Restart	Survived
12[16]	71 M	Non-small cell cell-lung cancer	Sitilimab, gemcitabine and carboplatin	After the 5th cycle of Sintilimab	Lichenoid dermatitis	Oral traditional Chinese herbal formula-modified Weiling decoction	Stop	Survived
13[17]	70 F	Advanced gastric malignancy	Sintilimab, oxaliplatin and tiggio	10 d after the first cycle	Toxic epidermal necrolysis	Intravenous methylprednisolone and immunoglobulin, adalimumab	Stop	Survived
14[18]	46 F	Lung adenocarcinoma	Sintilimab and QL1706 injection	2 wk after the first cycle	Aggravated rapidly with depigmentation	No additional treatment	Restart	Survived