TABLE 1.
Comparison of patients with NASH versus NAFL with respect to histological, clinical, and demographic characteristics
| Clinical and demographic characteristics | NAFL N = 16 | NASH N = 26 |
|---|---|---|
| Age, mean (SD) | 51.3 (12.8) | 50.4 (10.0) |
| Male, n (%) | 15 (94) | 21 (81) |
| Race/ethnicity | ||
| Non-Hispanic White | 16 (100) | 19 (73) |
| Non-Hispanic Black | 0 (0) | 1 (4) |
| Hispanic | 0 (0) | 2 (8) |
| Other | 0 (0) | 4 (15) |
| BMI, kg/m2 (SD) | 33.9 (5.8) | 33.6 (5.2) |
| Diabetes, n (%) | 4 (25) | 16 (62) |
| Fasting blood levels, mean (SD) | ||
| ALT (U/L) | 48.9 (24.2) | 98.5 (39.3)a |
| AST (U/L) | 36.6 (26.0) | 58.3 (25.7)b |
| Total cholesterol (mg/dl) | 198.2 (46.4) | 206.8 (39.6) |
| LDL-C (mg/dl) | 104.3 (30.0) | 116.4 (41.9) |
| HDL-C (mg/dl) | 43.6 (20.7) | 39.4 (11.9) |
| Triglyceride (mg/dl) | 269.2 (256.0) | 264.3 (99.9) |
| Platelet count (K/μl) | 230.9 (49.2) | 227.4 (60.4) |
| Hepatic histology, n (%) | ||
| Steatosis gradea | ||
| 0 | 0 (0) | 0 (0) |
| 1 | 9 (56) | 1 (4) |
| 2 | 6 (38) | 16 (62) |
| 3 | 1 (6) | 9 (34) |
| Inflammation gradea | ||
| 0 | 3 (19) | 0 (0) |
| 1 | 13 (81) | 11 (42) |
| 2 | 0 (0) | 14 (54) |
| 3 | 0 (0) | 1 (4) |
| Ballooning degenerationa | ||
| 0 | 11 (69) | 1 (4) |
| 1 | 5 (31) | 11 (42) |
| 2 | 0 (0) | 14 (54) |
| Fibrosis stagea | ||
| 0 | 16 (100) | 2 (8) |
| 1 | 0 (0) | 13 (52) |
| 2 | 0 (0) | 5 (20) |
| 3 | 0 (0) | 4 (16) |
| 4 | 0 (0) | 1 (4) |
Notes: Data are expressed as mean, and numbers within parenthesis represent either SD or percentage of patients.
a
p<0.01 different between NASH and simple steatosis.
b
p<0.05.
p-value from unpaired 2-tailed Student t-test.