Skip to main content
. 2023 Oct 12;7(11):e0284. doi: 10.1097/HC9.0000000000000284

FIGURE 2.

FIGURE 2

Liver expression of enzymes involved in phase II sulfonation and glucuronidation pathways are perturbed in patients with severe alcohol-associated liver disease. Heatmaps were created by log transforming TPM and grouping samples by disease categories, such as HC (n = 10), EAH (n = 12), AHL (n = 18), explant tissue from patients with sAH with liver transplant (ExAH, n = 10), NAFLD (n = 8), HCV (n = 9), and HCV_Cirr (n = 9). (A) Expression of sulfotransferases and phosphosulfate synthase enzymes that comprise the liver sulfonation pathway. (B) Expression of glucuronosyltransferases and phosphoglucomutases involved in the liver glucuronidation pathway. (C) Boxplots of SULT1A1 and SULT2A1 gene expression in TPM of RNA sequencing data from patients with various liver diseases. (D) Boxplots of UGT1A6 and UGT2B4. Error bars indicate SD, and (*) indicates q < 0.05. Abbreviations: AH, alcohol-associated hepatitis; AHL, AH with liver failure; EAH, early alcohol-associated hepatitis; ExAH, explant tissue from patients with severe AH after liver transplant; HC, healthy control; HCV_Cirr, HCV with cirrhosis; sAH, severe alcohol-associated hepatitis; SULT, sulfotransferase; TPM, transcripts per million; UGT, UDP glucuronosyltransferase.