FIGURE 3.

Meta-analysis reveals perturbations of phase II metabolism enzymes in 3 separate bulk RNA sequencing data sets. Violin plots were created by applying a random effects’ model on each of the individual fold changes to create the summarized diamonds, followed by a Bonferroni adjustment for p-values. (A) Log2 fold change, between healthy controls and sAH explant tissue, of sulfotransferases involved in the liver sulfonation pathway. (B) Log2 fold change of phosphoglucomutases involved in the liver glucuronidation pathway. Abbreviations: AH, alcohol-associated hepatitis; AHL, AH with liver failure; EAH, early alcohol-associated hepatitis; HC, healthy control; HCV_Cirr, HCV with cirrhosis; sAH, severe alcohol-associated hepatitis; SULT, sulfotransferase TPM, transcripts per million; UGT, UDP glucuronosyltransferase.