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. 2023 Oct 12;7(11):e0284. doi: 10.1097/HC9.0000000000000284

FIGURE 4.

FIGURE 4

Hepatic gene expression of enzymes involved in tryptophan metabolism is impaired with severe ALD. Heatmaps were created by log transforming transcripts per million and grouping samples by disease categories, such as HC (n = 10), early AH (n = 12), AH with liver failure (n = 18), explant tissue from patients with sAH with emergency liver transplant (ExAH, n = 10), NAFLD (n = 8), HCV (n = 9), and HCV_Cirr (n = 9). (A) Expression of enzymes involved in tryptophan metabolism pathways. (B) Boxplots of TDO2 and MAOA gene expression in transcripts per million from RNA-seq data of patients with various liver pathologies. Error bars indicate SD, and (*) indicates q < 0.05. Abbreviations: AH, alcohol-associated hepatitis; ALD, alcohol-associated liver disease; ExAH, explant tissue from patients with alcohol-associated hepatitis; HC, healthy control; HCV_Cirr, hepatitis C virus with cirrhosis; sAH, severe alcohol-associated hepatitis.