Table 2.
CSF and blood beta‐syn distribution in non‐prion RPD etiologies.
| Diagnostic categories of non‐prion RPD patients | n | CSF beta‐syn (pg/mL) Median (IQR) | n | Plasma beta‐syn (pg/mL) Median (IQR) |
|---|---|---|---|---|
| All neurodegenerative diseases | 52 | 268 (184–454) | 50 | 10.8 (3.3–25.9) |
| Alzheimer's disease | 42 | 281 (200–467) | 40 | 11.6 (3.0–26.8) |
| Dementia with Lewy bodies | 8 | 131.5 (71.5–252.5) | 8 | 8.7 (3.1–18.7) |
| Frontotemporal dementia | 2 | 243, 82 | 2 | 9.4, 36.2 |
| Vascular/mixed dementia and stroke | 10 | 201 (76.5–629) | 10 | 19.6 (1.5–65.4) |
| Immuno‐mediated, infectious encephalitis and other inflammatory/infective diseases | 27 | 493 (221–1284) | 25 | 7.3 (1.4–34.2) |
| Toxic/metabolic encephalopathies | 10 | 521 (193–952) | 10 | 13.2 (5.3–30.0) |
| Central nervous system malignancy | 5 | 659 (387–2772) | 3 | 2.8, 4.0, 0.8 |
Beta‐syn, beta‐synuclein; CSF, cerebrospinal fluid; IQR, interquartile range; RPD, rapidly progressive dementia.