Table 3.
Diagnostic accuracy of CSF and plasma beta‐syn in comparison with that of other CSF and blood biomarkers in the discrimination between sporadic Creutzfeldt‐Jakob disease and non‐prion RPDs.
| AUC | Cutoff | Sens (%) | Spec (%) | DeLong p vs. CSF beta‐syn | DeLong p vs. plasma beta‐syn | ||
|---|---|---|---|---|---|---|---|
| CSF beta‐syn | 0.949 ± 0.014 | > | 1313 pg/mL | 84.4 | 92.2 | – | 0.135 |
| Plasma beta‐syn | 0.914 ± 0.019 | > | 37.5 pg/mL | 84.7 | 84.0 | 0.135 | – |
| CSF t‐tau | 0.922 ± 0.017 | > | 1770 pg/mL | 86.0 | 87.7 | 0.212 | 0.765 |
| CSF 14‐3‐3 | 0.892 ± 0.013 | > | 16550 AU/mL | 94.0 | 73.6 | 0.028 | 0.447 |
| Plasma tau | 0.791 ± 0.032 | > | 4.1 pg/mL | 77.3 | 69.7 | <0.001 | 0.001 |
| Plasma NfL | 0.654 ± 0.040 | > | 50.2 pg/mL | 88.0 | 47.5 | <0.001 | <0.001 |
AUC, area under the curve; beta‐syn, beta‐synuclein; CSF, cerebrospinal fluid; NfL, neurofilament light chain; sens, sensitivity, spec, specificity; t‐tau, total tau protein.