Chart 3. Major risk factors for interstitial lung disease progression.^a .

• Advanced age • Male sex • Family history (short telomeres) • Clubbing of the fingers • Need for oxygen therapy • > 20% extent of fibrosis on HRCT • Extensive traction bronchiectasis on HRCT • FVC of < 50-65% predicted • DLCO of < 50% predicted • An SpO2 of < 85% during exercise • No identification or avoidance of antigens in CHP • Pulmonary hypertension

CHP: chronic hypersensitivity pneumonitis. ^aBased on Valenzuela & Cottin,⁽⁸⁾ as well as on other references.^(15-42)