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. 2023 Oct 2;13:1238332. doi: 10.3389/fonc.2023.1238332

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Copyright © 2023 Cai, Deng, Wang, Zhu, Huang, Du, Wang, Yu, Liu, Yang, Wang, Wang, Ma, Huang, Zhou, Zou, Zhang, Huang, Li, Qin, Xu, Guo and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Separation of tumor cells by microfluidic chips. (A) WBCs and Hela cells number after density gradient centrifugation, n=13. Data are presented as the median with interquartile range. (B) The recovered number of WBCs from samples with different WBCs densities, n=15. (C) Recovery rate of SK-BR-3 tumor cell from samples with different WBCs densities, n=15. (D) Recovery rate of different tumor cell lines in trapezoid microfluidics chip, n=15. (E) Recovery purity of different tumor cell lines in trapezoid microfluidics chip, n=15. (F) Comparison of recovery purity of Hela cell in different tumor cell densities between trapezoid (blue bar) and rectangle (orange bar) microfluidics chips, n=15. (G) Comparison of recovery rate in different tumor cell densities between trapezoid (blue bar) and rectangle (orange bar) microfluidics chips, n=15. Data are presented as the mean ± SD, error bars indicate s.e.m. NS, not significant; *p < 0.05, **p < 0.01, ***p < 0.001 by two-tailed Student t-test.