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. Author manuscript; available in PMC: 2023 Oct 16.
Published in final edited form as: Heart Vessels. 2015 Nov 12;31(7):1186–1195. doi: 10.1007/s00380-015-0768-8

Fig. 5.

Fig. 5.

A) Two regions of remodeling (R1, R2) were evident as indicated by the red arrows: R1=immediately adjacent to the hole, rich in VC, HA, and demonstrating alcian-blue staining in Movat-stained sections; R2=located interior to R1 relative to the hole-punch, rich in DCN, MMPs, Col III, and elastin. B) Decreased delineation (indicated by red arrow) in HOLE PML compared to CTRL. C) Visualization of picrosirius red-stained tissue under polarized light demonstrates disruption of collagen backbone in HOLE PML. Scale bars for all images represent 1 mm.