Table 3.

Comparative analysis of the temporal fold changes of protein and metabolite between patients in aggravation group and remission group.

Metabolites	Aggravation	Remission	P
n	29	12
ERC-BiP	1.66 (1.15, 2.22)	0.88 (0.74, 1.03)	0.001
Lactic acid	1.15 (0.89, 1.47)	1.04 (0.96, 1.26)	0.796
Pyruvic acid	1.02 (0.93, 1.26)	0.99 (0.92, 1.12)	0.456
Cholesterol	1.01 (0.96, 1.11)	1.03 (0.98, 1.07)	0.864
Melatonin	0.99 (0.80, 1.12)	0.83 (0.80, 1.25)	0.528
CRP	1.36 (0.76, 1.95)	0.52 (0.37, 0.85)	0.025
AGT	1.46 (1.20, 2.20)	0.80 (0.59, 0.98)	<0.001
Cer	1.50 (1.00, 2.47)	0.73 (0.50, 1.09)	0.001
SM	0.69 (0.34, 0.86)	1.04 (1.00, 1.49)	0.001
Oxaloacetic acid	1.24 (0.78, 1.69)	0.97 (0.73, 1.06)	0.187
Malic acid	0.77 (0.44, 0.93)	0.95 (0.85, 1.26)	0.071
α-ketoglutaric acid	0.97 (0.59, 1.48)	1.43 (0.96, 1.95)	0.136
Isocitrate acid	1.32 (0.85, 1.85)	1.17 (0.98, 1.59)	0.931
Succinic acid	0.92 (0.61, 1.32)	0.90 (0.63, 1.56)	0.864