TABLE 2.

Life’s Essential 8 and incidence of chronic kidney disease

	Cases/person-y	Model 1		Model 2		Model 3
		HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
		CKD
Cardiovascular health metrics
Low	168/78,915.6	Ref		Ref		Ref
Moderate	1542/1,175,936.4	0.54 (0.46, 0.63)	<0.001	0.58 (0.49, 0.68)	<0.001	0.61 (0.52, 0.72)	<0.001
High	226/322,509.6	0.35 (0.29, 0.43)	<0.001	0.40 (0.33, 0.49)	<0.001	0.43 (0.35, 0.53)	<0.001
Per SD increment in LE8		0.16 (0.12, 0.22)	<0.001	0.21 (0.15, 0.27)	<0.001	0.23 (0.18, 0.31)	<0.001
Subscale
Per SD increment in behavior scale		0.26 (0.21, 0.33)	<0.001	0.31 (0.24, 0.39)	<0.001	0.34 (0.27, 0.43)	<0.001
Per SD increment in biological scale		0.66 (0.54, 0.80)	<0.001	0.68 (0.56, 0.83)	<0.001	0.70 (0.57, 0.85)	<0.001

CI, confidence interval; CKD, chronic kidney disease; HR, hazard ratio; LE8, Life’s Essential 8; Ref, reference; SD, standard deviation.

Model 1 was adjusted for age, ethnicity, and sex.

Model 2: Model 1 + Townsend deprivation index, education, and average household income.

Model 3: Model 2 + C-reactive protein and cancer at baseline.

Behavior scale and biological scale were mutually adjusted for subscale analyses.