TABLE 3.

Stratified analyses for association between Life’s Essential 8 and hazard of chronic kidney disease

Subgroups	Cardiovascular health metrics
	Low	Moderate	High	P-trend	P-interaction
Age (y)					0.168
<60	1 (reference)	0.58 (0.45, 0.76)	0.42 (0.30, 0.58)	<0.001
≥60	1 (reference)	0.66 (0.53, 0.81)	0.43 (0.33, 0.56)	<0.001
Sex					0.468
Female	1 (reference)	0.60 (0.47, 0.72)	0.45 (0.34, 0.60)	<0.001
Male	1 (reference)	0.61 (0.50, 0.76)	0.40 (0.29, 0.54)	<0.001
Ethnicity					0.401
Non-White	1 (reference)	0.68 (0.24, 1.96)	0.49 (0.13, 1.83)	0.290
White	1 (reference)	0.61 (0.51, 0.71)	0.43 (0.35, 0.53)	<0.001
Townsend deprivation index					0.669
Low (Q1)	1 (reference)	0.50 (0.34, 0.73)	0.38 (0.24, 0.60)	<0.001
Intermediate (Q2–Q4)	1 (reference)	0.58 (0.47, 0.71)	0.41 (0.32, 0.54)	<0.001
High (Q5)	1 (reference)	0.79 (0.56, 1.11)	0.52 (0.32, 0.83)	0.005
Education					0.790
College/university degree	1 (reference)	0.66 (0.54, 0.79)	0.45 (0.35, 0.58)	<0.001
Under college/university degree	1 (reference)	0.49 (0.36, 0.67)	0.36 (0.25, 0.53)	<0.001
Household income					0.052
< Median	1 (reference)	0.60 (0.50, 0.72)	0.45 (0.37, 0.56)	<0.001
≥ Median	1 (reference)	0.61 (0.44, 0.86)	0.59 (0.40, 0.86)	<0.001
CRP					0.060
< Median	1 (reference)	0.66 (0.43, 0.86)	0.47 (0.30, 0.76)	<0.001
≥ Median	1 (reference)	0.63 (0.53, 0.75)	0.50 (0.39, 0.65)	<0.001
Baseline cancer					0.383
No	1 (reference)	0.60 (0.51, 0.71)	0.45 (0.37, 0.56)	0.683
Yes	1 (reference)	0.74 (0.42, 11.33)	0.28 (0.13, 0.62)	<0.001

Data are expressed as hazard ratio and 95% confidence interval. Model was adjusted for age, ethnicity, sex, Townsend deprivation index, education, average household income, CRP, and cancer at baseline. CRP, C-reactive protein; Q, quartile.