Table 3.

Adverse events in the intention-to-treat population

	Cloxacillin plus fosfomycin (n = 104)	Cloxacillin alone (n = 110)	Risk difference % (95% CI)	P value*
Any serious adverse event at TOC	42 (40.4%)	48 (43.6%)	−3.22 (−17.41–10.91)	0.732
Main adverse events at TOCa
Hypokalemia (<3 mmol L−1)	18 (17.31%)	11 (10%)	7.31 (−2.81–17.42)	0.173
Hypocalcemia (<2.0 mmol L−1)	15 (14.42%)	5 (4.55%)	9.92 (1.15–18.61)	0.018
Acute heart failure	6 (5.77%)	6 (5.45%)	0.27 (−6.17–6.8)	1.000
Gastrointestinal disorders	7 (6.73%)	6 (5.45%)	1.23 (−7.58–6.39)	0.917

*The P values were obtained from a two-sided test for differences in proportions.

^aAdverse events occurring in >4 patients.