表 2. Associations of adulthood BMI with the concentration of obesity-related breast cancer risk biomarkers.
成年后期BMI与肥胖相关乳腺癌风险标志物浓度的关联
Model | Adiponectin | Resistin | C-reactive protein | Insulin-like growth factor binding protein-3 |
Soluble leptin receptor | |||||||||
β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | |||||
# Low weight group (n=7) was not included in this analysis. Model 1 was adjusted for age at enrollment (continuous); Model 2 was adjusted for age at enrollment (continuous), highest education attained (primary school or lower, primary and junior high school, and senior high school and college), occupation (administration; manufacturing, construction, service, business, and farming; unemployed, retired and others), age of menarche (<14 or ≥14 years old), menopause status (premenopausal or postmenopausal), history of livebirth(s) (yes or no), smoking (yes or no) and drinking (yes or no). | ||||||||||||||
Model 1# | ||||||||||||||
Normal weight | Reference | Reference | Reference | Reference | Reference | |||||||||
Overweight | −0.102 (−0.207, 0.003) | 0.056 | 0.010 (−0.213, 0.232) | 0.933 | 0.410 (0.174, 0.647) | 0.001 | 0.021 (−0.144, 0.185) | 0.805 | 0.338 (0.177, 0.498) | <0.001 | ||||
Obese | −0.236 (−0.399, −0.073) | 0.005 | 0.017 (−0.328, 0.363) | 0.921 | 0.902 (0.535, 1.268) | <0.001 | 0.068 (−0.187, 0.322) | 0.602 | 0.592 (0.343, 0.840) | <0.001 | ||||
ΔBMI (per 1 kg/m2) | −0.028 (−0.045, −0.010) | 0.002 | 0.013 (−0.025, 0.050) | 0.502 | 0.103 (0.063, 0.143) | <0.001 | 0.011 (−0.016, 0.039) | 0.424 | 0.093 (0.067, 0.120) | <0.001 | ||||
Model 2# | ||||||||||||||
Normal weight | Reference | Reference | Reference | Reference | Reference | |||||||||
Overweight | −0.109 (−0.217, −0.001) | 0.049 | 0.008 (−0.201, 0.217) | 0.938 | 0.405 (0.164, 0.647) | 0.001 | 0.024 (−0.143, 0.191) | 0.776 | 0.333 (0.171, 0.496) | <0.001 | ||||
Obese | −0.231 (−0.399, −0.063) | 0.007 | 0.011 (−0.312, 0.334) | 0.947 | 0.832 (0.459, 1.206) | <0.001 | 0.023 (−0.234, 0.281) | 0.858 | 0.548 (0.297, 0.799) | <0.001 | ||||
ΔBMI (per 1 kg/m2) | −0.026 (−0.045, −0.008) | 0.006 | 0.015 (−0.020, 0.051) | 0.398 | 0.095 (0.054, 0.137) | <0.001 | 0.008 (−0.020, 0.037) | 0.573 | 0.090 (0.063, 0.117) | <0.001 |