表 3. Associations of early adulthood BMI with the concentration of obesity-related breast cancer risk biomarkers.
成年早期BMI与肥胖相关乳腺癌风险标志物浓度的关联
| Model | Adiponectin | Resistin | C-reactive protein | Insulin-like growth factor binding protein-3 |
Soluble leptin receptor | |||||||||
| β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | |||||
| Model 1, Adjusted for age at enrollment (continuous); Model 2, adjusted for age at enrollment (continuous), education (less than primary school, primary and junior high school, and senior high school and college), occupation (administration; manufacturing, construction, service, business, and farming; unemployed, retired, and others), age of menarche (<14 or ≥14 years old), menopause status (premenopausal, postmenopausal), history of livebirth (yes or no), smoking (yes or no) and drinking (yes or no). | ||||||||||||||
| Model 1 | ||||||||||||||
| Normal weight | Reference | Reference | Reference | Reference | Reference | |||||||||
| Low weight | −0.035 (−0.199, 0.128) |
0.669 | 0.084 (−0.256, 0.424) |
0.627 | 0.457 (0.090, 0.824) |
0.015 | 0.193 (−0.055, 0.441) |
0.127 | 0.162 (−0.088, 0.412) |
0.205 | ||||
| Overweight | 0.001 (−0.136, 0.138) |
0.990 | 0.076 (−0.213, 0.364) |
0.606 | 0.121 (−0.191, 0.432) |
0.447 | −0.304 (−0.515, −0.094) |
0.005 | 0.128 (−0.084, 0.340) |
0.235 | ||||
| Obese | 0.072 (−0.356, 0.500) |
0.742 | −0.438 (−1.329, 0.453) |
0.335 | 0.378 (−0.584, 1.340) |
0.440 | 0.374 (−0.276, 1.025) |
0.259 | 0.158 (−0.498, 0.813) |
0.637 | ||||
| ΔBMI (per 1 kg/m2) | 0.007 (−0.012, 0.026) |
0.457 | −0.030 (−0.069, 0.009) |
0.135 | −0.007 (−0.050, 0.036) |
0.746 | −0.040 (−0.069, −0.011) |
0.007 | 0.007 (−0.022, 0.036) |
0.638 | ||||
| Model 2 | ||||||||||||||
| Normal weight | Reference | Reference | Reference | Reference | Reference | |||||||||
| Low weight | −0.027 (−0.195, 0.140) |
0.748 | 0.139 (−0.185, 0.463) |
0.399 | 0.503 (0.128, 0.878) |
0.009 | 0.173 (−0.079, 0.425) |
0.179 | 0.158 (−0.095, 0.411) |
0.220 | ||||
| Overweight | 0.012 (−0.128, 0.152) |
0.865 | 0.088 (−0.185, 0.361) |
0.526 | 0.110 (−0.206, 0.425) |
0.495 | −0.298 (−0.510, −0.086) |
0.006 | 0.126 (−0.087, 0.339) |
0.246 | ||||
| Obese | 0.077 (−0.359, 0.513) |
0.730 | −0.471 (−1.313, 0.370) |
0.271 | 0.306 (−0.668, 1.279) |
0.538 | 0.421 (−0.233, 1.076) |
0.206 | 0.136 (−0.522, 0.794) |
0.685 | ||||
| ΔBMI (per 1 kg/m2) | 0.009 (−0.010, 0.029) |
0.330 | −0.031 (−0.068, 0.006) |
0.106 | −0.013 (−0.056, 0.031) |
0.568 | −0.039 (−0.068, −0.010) |
0.009 | 0.006 (−0.023, 0.035) |
0.701 | ||||