表 4. Associations of adulthood weight gain with the concentration of obesity-related breast cancer risk biomarkers^#.

成年期增重与肥胖相关乳腺癌风险标志物浓度的关联^#

Variable	Adiponectin			Resistin			C-reactive protein			Insulin-like growth factor binding protein-3			Soluble leptin receptor
	β (95% CI)	P		β (95% CI)	P		β (95% CI)	P		β (95% CI)	P		β (95% CI)	P
# Adjusted for age at enrollment (continuous), highest education attained (primary school or lower, primary and junior high school, senior high school, and college), occupation (administration; manufacturing, construction, service, business, and farming; unemployed, retired, and others), age of menarche (<14 or ≥14 years old), menopause status (premenopausal or postmenopausal), history of livebirth(s) (yes or no), smoking (yes or no), drinking (yes or no) and BMI at 20 years old (continuous).
−2.50-<2.50 kg	Reference			Reference			Reference			Reference			Reference
2.50-<5.00 kg	−0.189 (−0.383, 0.006)	0.057		0.202 (−0.170, 0.573)	0.286		0.179 (−0.257, 0.615)	0.420		0.176 (−0.116, 0.468)	0.237		0.152 (−0.127, 0.432)	0.285
≥5.00 kg	−0.185 (−0.320, −0.049)	0.008		0.212 (−0.049, 0.474)	0.111		0.171 (−0.136, 0.478)	0.275		0.389 (0.183, 0.594)	<0.001		0.245 (0.048, 0.442)	0.015
Continuous (per 1 kg)	−0.012 (−0.021, −0.004)	0.006		0.019 (0.001, 0.036)	0.036		0.026 (0.006, 0.046)	0.012		0.023 (0.010, 0.037)	0.001		0.020 (0.007, 0.033)	0.003
Average annual weight gain (per 1 kg/year)	−0.338 (−0.591, −0.084)	0.009		0.717 (0.220, 1.213)	0.005		0.595 (0.024, 1.167)	0.041		0.739 (0.351, 1.128)	<0.001		0.508 (0.139, 0.877)	0.007