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. 2023 Oct 9;29(10):2559–2569. doi: 10.1038/s41591-023-02598-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–d, We identified four patterns of ctDNA kinetics: 13 patients showed ctDNA maxMAF clearance at C2D1, as shown here for patient BR360006 (a); two patients showed ctDNA maxMAF clearance at C3D1, as shown here for patient BR360015 (b); two patients had ctDNA reduction >85% but <100%, as shown here for patient BR360010 (c); and 18 patients showed ctDNA persistence throughout the timepoints analyzed, as shown here for patient BR360004 (d). Timepoints (C1D1, C2D1 and C3D1) are shown at the top of each panel, alongside the maxMAF of tumor-derived variants detected at each timepoint. Stacked area plots represent MAFs of individual tumor-specific variants as measured in liquid biopsies at baseline and on-therapy timepoints. Of note, the plot does not reflect the unknown hierarchical structure of tumor subclones harboring mutations, and, as such, the height of the area plot indicates the sum of MAFs from all mutations at each timepoint.