TABLE 2.
Amino acid changes encoded by mutations in the grlA, grlB, and gyrA gene locia and corresponding ciprofloxacin MICs
| Amino acid change(s)
|
No. of strains with the following ciprofloxacin MIC (μg/ml):
|
Total no. of strains | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GrlA | GrlB | GyrA | ≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | |
| —b | — | — | 11 | 15 | 6 | 3 | 1 | 36 | ||||||||
| — | Ser-112→Arg | 1 | 1 | |||||||||||||
| Glu-422→Asp | Glu-88→Lys | 1 | 1 | |||||||||||||
| Ile-45→Met | Glu-422→Asp | — | 2 | 2 | ||||||||||||
| Pro-144→Ser | — | — | 1 | 1 | ||||||||||||
| Glu-422→Asp | — | 1 | 1 | 1 | 3 | |||||||||||
| Ser-80→Phe | — | — | 1 | 1 | ||||||||||||
| — | Ser-84→Leu | 4 | 22 | 13 | 7 | 1 | 47 | |||||||||
| — | Glu-88→Lys | 1 | 9 | 2 | 12 | |||||||||||
| — | Ser-84→Leu; Gly-106→Asp | 1 | 1 | |||||||||||||
| Asp-432→Gly | Ser-84→Leu | 1 | 1 | |||||||||||||
| Ser-80→Phe; Glu-84→Val | — | Glu-88→Lys | 1 | 2 | 1 | 4 | ||||||||||
| Ser-80→Phe; Ala-48→Thr | — | Ser-84→Leu | 2 | 1 | 3 | |||||||||||
| Pro-451→Ser | Ser-84→Leu | 1 | 1 | |||||||||||||
| Ser-80→Phe; Ile-45→Met | Glu-422→Asp | — | 1 | 1 | ||||||||||||
| Ser-80→Phe; Val-41→Gly; Ile-45→Met | Glu-422→Asp | Ser-84→Leu | 1 | 1 | ||||||||||||
a
No amino acid changes encoded by mutations in the gyrB gene have been observed.
b
—, no amino acid change.