Table 3.

Relationship between hyperparathyroidism and PPI use (dichotomised by calcium supplement use, excluding those on thiazide and loop diuretics)

	Calcium supplement use (Yes, n = 1179), (no, n = 1522)	β coefficient	Odds ratio*	95% confidence interval		p value
				Lower	Upper
Model 1	On calcium	0.32	1.89	1.19	2.98	0.007
	Not on calcium	0.22	1.54	1.10	2.16	0.011
Model 2	On calcium	0.29	1.80	1.13	2.86	0.013
	Not on calcium	0.12	1.28	0.91	1.82	0.161
Model 3a	On calcium	0.29	1.80	1.13	2.87	0.013
	Not on calcium	0.12	1.28	0.90	1.81	0.166
Model 3b	On calcium	0.30	1.82	1.14	2.90	0.012
	Not on calcium	0.13	1.28	0.91	1.82	0.159

*Reference group: PPI non-users

Model 1: adjusted for age, sex, serum 25(OH)D^a, eGFR^a

Model 2: model 1 and BMI, timed up and go^a, daily dairy intake

Model 3a: model 2 and bisphosphonates

Model 3b: model 2 and current glucocorticoid use

^aKnotted spline function applied due to non-linearity between the logit of hyperparathyroidism and dependant variable

*PTH > 65 (n = 87 in calcium supplements users and n = 179 in non-calcium supplement users)