TABLE 2.
Values of pharmacokinetic parameters for ciprofloxacin given i.v. at 400 mg q8h for the treatment of severe sepsisa
| Day | Cmax (mg/liter) | Cmin (mg/liter) | t1/2 (h) | CL (liter/h/ kg) | V (liters/ kg) | AUC0–8 (mg · h/ liter) |
|---|---|---|---|---|---|---|
| 0 (n = 18) | 6.01 (1.93) | 0.6 (0.5) | 3.9 (1.7) | 0.4 (0.2) | 1.4 (0.3) | 13.3 (3.8) |
| 2 (n = 17) | 6.68 (2.01) | 0.7 (0.4) | 3.2 (0.9) | 0.4 (0.2) | 1.2 (0.3) | 16.8 (5.4) |
| 6–8 (n = 16) | 6.45 (1.54) | 0.6 (0.4) | 3.3 (2.0) | 0.4 (0.1) | 1.3 (0.5) | 15.5 (4.7) |
a
Values are given as means (SDs). There was no statistical significance between the groups (Student’s t test).