Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 16;14:6516. doi: 10.1038/s41467-023-42146-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a–d Top view and side view of superimposition of M4-GII.4 P-domain complex onto the AB dimer of HOV VLP cryo-EM structure (PDB ID:7MRY) in “resting” state. e–h Top and side view of M4-GII.4 P-domain complex superimposed on the AB dimer of the VLP in the “raised” state, which was modeled in 8.0 Å GII.4c cryo-EM map in T = 3 symmetry (EMD-10756). The VP1 subunits are colored (M4 bound dimer, magenta; neighboring dimer, blue). Nanobody M4 is shown in green. i Schematic of M4 neutralization mechanism. Cartoon representation of the capsid (designed using Adobe Illustrator) in the resting (as in a) and the raised state (as in e) shown with P-domain dimers in blue, S domain in green, and linker region in red. j Negative-stain EM analysis of GII.4 and GII.3 VLPs in the presence or absence of M4.