Table 3.
Generalized linear mixed models of childhood ethnoracial minority density predicting right fusiform and right insula cortical thicknesses among minorities at clinical high-risk for psychosis stratified by social engagement.
Right Fusiform and Greater SE (Model E; n = 42) |
Right Fusiform and Lower SE (Model F; n = 122) |
Right Insula and Greater SE (Model G; n = 42) |
Right Insula and Lower SE (Model H; n = 122) |
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Parameters | β | SE | 95% CI | p | β | SE | 95% CI | p | β | SE | 95% CI | p | β | SE | 95% CI | p |
Intercept | 1.53 | 1.01 | −0.45 to 3.50 | 0.138 | 0.84 | 0.54 | −0.22 to 1.90 | 0.124 | 2.09 | 0.94 | 0.24 to 3.94 | 0.033 | 1.69 | 0.52 | 0.66 to 2.71 | 0.002 |
Age | −0.08 | 0.05 | −0.18 to 0.03 | 0.164 | −0.05 | 0.03 | −0.10 to 0.00 | 0.069 | −0.11 | 0.05 | −0.21 to −0.01 | 0.039 | −0.09 | 0.03 | −0.14 to −0.03 | 0.002 |
Female Sex | −0.65 | 0.31 | −1.26 to −0.04 | 0.043 | −0.16 | 0.17 | −0.49 to 0.18 | 0.355 | −0.31 | 0.30 | −0.89 to 0.28 | 0.315 | −0.21 | 0.17 | −0.54 to 0.13 | 0.233 |
Family History of Mental Illnesses | 0.21 | 0.33 | −0.44 to 0.87 | 0.524 | 0.05 | 0.18 | −0.30 to 0.40 | 0.768 | 0.16 | 0.31 | −0.46 to 0.77 | 0.624 | −0.09 | 0.18 | −0.44 to 0.26 | 0.613 |
Area-level Socioeconomic Deprivation | 0.02 | 0.38 | −0.74 to 0.77 | 0.966 | −0.54 | 0.25 | −1.04 to −0.05 | 0.035 | 0.32 | 0.36 | −0.38 to 1.02 | 0.375 | −0.55 | 0.24 | −1.01 to −0.09 | 0.024 |
Area-level Ethnoracial Minority Density | 0.03 | 0.33 | −0.61 to 0.67 | 0.921 | 0.72 | 0.22 | 0.29 to 1.14 | 0.002 | −0.28 | 0.29 | −0.85 to 0.29 | 0.338 | 0.57 | 0.20 | 0.18 to 0.97 | 0.007 |
Pseudo-R2 (fixed effects) | 17.8% | 18.1% | 14.9% | 19.0% |
SE social engagement, CHR-P clinical high risk for psychosis.
Social engagement was dichotomized into higher and lower based upon its median value of 4.
All models used generalized linear mixed multivariate models with the following fixed effects (age, female sex, clinical high risk for psychosis status, family history of mental illnesses, and area-level deprivation) and random effects (counties and sites).
Model E tested the associations between all fixed effects and right fusiform cortical thickness among CHR-P minorities with greater social engagement (n = 42).
Model F tested the associations between all fixed effects and right fusiform cortical thickness among CHR-P minorities with lower social engagement (n = 122).
Model G tested the associations between all fixed effects and right insula cortical thickness among CHR-P minorities with greater social engagement (n = 42).
Model H tested the associations between all fixed effects and right insula cortical thickness among CHR-P minorities with lower social engagement (n = 122).
All significant associations (p < 0.05) are shown in bold.