Table 1.
Lipids with the highest PIS scores.
| Identifier | Full name | Category | Class | PIS |
|---|---|---|---|---|
| CER.D16.1.22.0 | Cer (d16:1/22:0) | sphingolipids | ceramide | 0.158 |
| PI.37.6 | PI (37:6) | glycerophospholipids | phosphatidylinositol | 0.157 |
| CE.20.4....OH | CE (20:4) [+OH] | Neutral/Other | oxidised lipids | 0.155 |
| LPE.20.4...SN1 | LPE (20:4) [sn1] | glycerophospholipids | Lysophosphatidylethanolamine | 0.144 |
| PE.P.19.0.20.4...A | PE (P-19:0/20:4) (a) | glycerophospholipids | alkenylphosphatidylethanolamine | 0.142 |
| PE.P.17.0.20.4...A | PE (P-17:0/20:4) (a) | glycerophospholipids | alkenylphosphatidylethanolamine | 0.139 |
| PC.O.16.0.20.3 | PC (O-16:0/20:3) | glycerophospholipids | alkylphosphatidylcholine | 0.133 |
| CER.D18.1.20.0 | Cer (d18:1/20:0) | sphingolipids | ceramide | 0.126 |
| CER.D19.1.20.0 | Cer (d19:1/20:0) | sphingolipids | ceramide | 0.118 |
| PI.34.1 | PI (34:1) | glycerophospholipids | phosphatidylinositol | 0.115 |
| PE.P.15.0.20.4...B | PE (P-15:0/20:4) (b) | glycerophospholipids | alkenylphosphatidylethanolamine | 0.114 |
| PE.P.16.0.20.5 | PE (P-16:0/20:5) | glycerophospholipids | alkenylphosphatidylethanolamine | 0.110 |
| CER.D18.1.24.1 | Cer (d18:1/24:1) | sphingolipids | ceramide | 0.109 |
| LPE.20.4...SN2 | LPE (20:4) [sn2] | glycerophospholipids | Lysophosphatidylethanolamine | 0.101 |
| PE.P.18.0.22.5...N6 | PE (P-18:0/22:5) (n6) | glycerophospholipids | alkenylphosphatidylethanolamine | 0.101 |
| PC.P.16.0.20.5 | PC (P-16:0/20:5) | glycerophospholipids | alkenylphosphatidylcholine | 0.100 |
| LPE.18.2...SN1 | LPE (18:2) [sn1] | glycerophospholipids | Lysophosphatidylethanolamine | 0.097 |
| DE.20.4 | DE (20:4) | Neutral/Other | dehydrocholesteryl ester | 0.097 |
Using the phenotype influence score obtained through c-SWAT, highly AD-associated lipids were identified.