TABLE 2.

PAEs and PAE-SMEs of compounds^a

Drug	PAE (h)		PAE-SMEb (h)
	Range	Mean	Range	Mean
Levofloxacin	0.5–4.5	2.5	1–5/1–6/2–8c	2.8/3.5/5.4
Ofloxacin	1–4.5	2.4	1–5/1–5/2–8d	2.6/3.3/5.0
Ciprofloxacin	0.5–6.5	2.3	1–4.5/1–8/1–7e	2.7/3.6/3.9
Erythromycin	1–5	2.5	1–8/1–8/1–6f	3.0/3.5/3.3
Azithromycin	1–4	1.9	1–4/1–5/1–5g	2.2/2.3/2.2
Clarithromycin	1–6	2.3	1–7/1–8/1–5h	3.5/4.0/3.3

^aRange of values (arithmetic mean of two assays for each strain) and arithmetic mean of values for all strains tested are given. PAEs and PAE-SMEs were not determined for nine strains for which the macrolide MICs were ≥512.0 μg/ml. 

^bPAE-SME values at sub-MICs of 0.125/0.25/0.5 times the MIC. 

^cOne, 2, and 12 strains had rapid bactericidal activity at 0.125, 0.25, and 0.5 times the MIC, respectively. 

^dOne, 2, and 12 strains had rapid bactericidal activity at 0.125, 0.25, and 0.5 times the MIC, respectively. 

^eTwo, 3, and 11 strains had rapid bactericidal activity at 0.125, 0.25, and 0.5 times the MIC, respectively. 

^fTwo strains had rapid bactericidal activity at 0.5 times the MIC. 

^gOne, one, and two strains had rapid bactericidal activity at 0.125, 0.25, and 0.5 times the MIC, respectively. 

^hTwo strains had rapid bactericidal activity at 0.5 times the MIC.