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. 2023 Oct 16;9:378. doi: 10.1038/s41420-023-01675-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The clustering heatmap for HOX gene expression profile between PCa tissues and the corresponding normal samples. B The gene-gene interaction network of HOX genes based on generated GeneMANIA and STRING. C Data about HOXA5 expression in PCa tissues and normal prostate samples were obtained from the The Cancer Genome Atlas (TCGA) dataset based on the TNMplot database. D Representative images of IHC staining of HOXA5 on paired normal and prostate cancer tissue samples. Images were taken at 100× and 400× magnifications. E HOXA5 mRNA level in paired PCa tissues and adjacent normal tissues. F Representative images of HOXA5 expression detected by Western Blot assay. *P < 0.05, **P < 0.01. Results were presented as mean ± SD.