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. 2023 Oct 16;14:6509. doi: 10.1038/s41467-023-42233-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b PPIs between E3 ligases and targets. c PROTAC tractable targets highlighted in the PROTACtable genome and MAPD in human genome. d Interactions between E3 ligases and PROTAC tractable cancer targets. Top barplot showing the number of targets interacting with E3 ligases. Left and right side barplot showing MAPD score of targets. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were experimentally explored in PROTAC experiment.