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. 2023 Oct 16;14:6509. doi: 10.1038/s41467-023-42233-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Distribution of the number of available structures of E3 ligases. b The number of protein structures of E3 ligases. c, d Distribution of mean of the probability of essentiality of E3 ligases by CRISPR and RNAi. e Ridgeplot showing the distribution of tumor-essential E3 ligases in both datasets. f Sankey plot showing cellular localization of E3 ligases from different data sources. g The cellular localizations of E3 ligases. h Outer ring showing E3 ligases with available PPI interface and inner ring showing the distribution of origins of PPI interface. i E3 ligases with top number of PPI interfaces. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were experimentally explored in PROTAC experiment.