Table 3.
Significantly altered non-lipid biochemicals from Volcano plot with twofold change and p-value < 0.05 in male mice (N = 5 for each hypoxic and normoxic group.
| Biochemicals | log2 (FC) | − Log10 (P) | Pathway/metabolite category | |
|---|---|---|---|---|
| Significant increase | Pantetheine | 13.497 | 2.629 | Pantothenate and CoA biosynthesis |
| Sorbitol | 13.232 | 1.3491 | Fructose and mannose degradation | |
| SAICAR | 13.051 | 1.9493 | Purine metabolism | |
| Galactonic acid | 12.16 | 1.6526 | Galactitol and galactonate degradation | |
| l-Homoserine | 11.466 | 1.7508 | Methionine metabolism | |
| myo-Inositol | 10.538 | 3.0587 | Inositol metabolism | |
| Betaine | 10.448 | 1.3958 | Betaine metabolism | |
| Glutamic acid, gamma-methyl ester | 9.4995 | 1.4527 | Glutamic acid and derivatives | |
| l-Arabitol | 9.2328 | 1.344 | Sugar alcohol | |
| Urea | 7.4236 | 1.7868 | Urea cycle | |
| l-Cysteine | 5.5896 | 2.2174 | Methionine metabolism | |
| Adenosine monophosphate | 4.944 | 2.1141 | Purine metabolism | |
| Succinyladenosine | 4.941 | 1.8023 | Purine nucleoside | |
| 4-Trimethylammoniobutanoic acid | 4.3663 | 1.7112 | Carnitine synthesis | |
| Acetyl-CoA | 4.0512 | 1.9797 | Fatty acid metabolism | |
| Inosinic acid | 3.8745 | 1.6973 | Purine metabolism | |
| Thiamine pyrophosphate | 3.5825 | 2.1263 | Thiamine metabolism | |
| Orotidine | 3.3748 | 1.5296 | Pyrimidine metabolism | |
| Uridine 5ʹ-monophosphate | 2.8874 | 1.3929 | Pyrimidine metabolism | |
| Guanosine monophosphate | 2.8655 | 1.4323 | Purine metabolism | |
| Alpha-Tocopherol | 2.6389 | 1.6576 | Active form of vitamin E | |
| AICAR | 2.1741 | 1.4138 | Purine metabolism | |
| N-Methyl-proline | 1.7265 | 1.3718 | Proline and derivatives | |
| l-Cysteinylglycine disulfide | 1.0897 | 1.5796 | Dipeptide | |
| Significant decrease | Pyroglutamic acid | − 1.9716 | 1.3723 | Glutathione metabolism |
| Xylitol | − 2.4925 | 1.3737 | Sugar alcohol | |
| l-Glutamic acid | − 3.641 | 1.7814 | Glutamate metabolism | |
| 3 beta-Hydroxy-5-cholestenoate | − 4.3007 | 1.8348 | Primary bile acid biosynthesis pathway | |
| Cysteine-S-sulfate | − 4.7517 | 1.4311 | Cysteine biosynthesis | |
| Deoxyinosine | − 9.085 | 1.7714 | Purine metabolism | |
| Spermine | − 11.513 | 2.989 | Arginine and proline metabolism | |
| Phosphoenolpyruvic acid | − 13.415 | 1.6534 | Glycolysis |
SICAR succinylaminoimidazolecarboxamide ribotide, AICAR 5-aminoimidazole-4-carboxamide ribonucleoside.