Table 1.
Individual and group mean ED50 values (95% confidence limits) for oxycodone following either a 60-min or 5-min pretreatment of vehicle, (±)VK4-116, or (±)VK4-40 in an assay of thermal nociception at 50 °C.
| 50 °C (60-min for vehicle, (±)VK4-116 and (±)VK4-40) | M1473 ED50 | M1503 ED50 | M1414 ED50 | Group ED50 values (95% CL) |
|---|---|---|---|---|
| Vehicle | 0.17 | 0.17 | 0.16 | 0.17 (0.16, 0.18) |
| (±)VK4-116 (10 mg/kg, IV) | 0.11 | 0.06 | 0.11 | 0.09 (0.06, 0.14) |
| (±)VK4-40 (3.2 mg/kg, IV) | 0.06 | 0.06 | > | >0.06 (0.06, 0.06) |
| Naltrexone (0.032 mg/kg, IM) | 2.26 | 1.34 | 2.26 | 1.9 (1.35, 2.67) |
| 50 °C (5-min for vehicle and (±)VK4-40) | ||||
| Vehicle | 0.06 | 0.17 | 0.3 | 0.14 (0.06, 0.38) |
| (±)VK4-40 (1 mg/kg, IV) | 0.17 | 0.18 | 0.26 | 0.2 (0.15, 0.26) |
| (±)VK4-40 (3.2 mg/kg, IV) | 0.1 | 0.06 | 0.56 | 0.15 (0.04, 0.57) |
> denotes an ED50 value could not be calculated because no oxycodone dose produced >50%MPE.
Naltrexone was administered as a 30-min pretreatment.