REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, peptides, and recombinant proteins
Brigatinib	MedChemExpress	Cat#HY-12857
C75	Sigma-Aldrich	Cat#C5490
Doxorubicin	Sigma-Aldrich	Cat#D5220
Fetal Bovine Serum	Gibco	Cat#16000044
Leflunomide	Sigma-Aldrich	Cat#L5025
Penicillin/Streptomycin	Gibco	Cat#15-140-122
Methionine deficient media	Gibco	Cat#A1451701
Critical commercial assays
CCK8 kit	Abcam	Cat#ab228554
Deposited data
Code availability	This paper	https://github.com/kirksmi/BreastCancerClustering
METABRIC microarray data	European Genome-Phenome Archive	https://ega-archive.org accession number: EGAD00010000210, EGAD00010000211, and EGAD00010000212.
METABRIC copy-number and mutation data	cbioportal	https://www.cbioportal.org
TCGA mRNA-seq and clinical data	UCSC Xena	http://xena.ucsc.edu
Drug sensitivity data	ArrayExpress E-MTAB-181	https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-181
Metabolomics data	Terunuma et al. (GSE37751)	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871244/
Experimental models: Cell lines
MDA-MB-231	ATCC	ATCC HTB-26
MDA-MB-468	ATCC	ATCC HTB-132
MCF7	ATCC	ATCC HTB-22
T47D	ATCC	ATCC HTB-133
Software and algorithms
Consensus clustering	Gene pattern version 2.0, GSEA	http://www.broadinstitute.org/gsea/
GraphPad Prism v8	GraphPad prism software	https://www.graphpad.com/features
MSigDB	The Broad Institute	http://software.broadinstitute.org/gsea/msigdb/index.jsp
Morpheus	Broad institute	https://software.broadinstitute.org/morpheus/
Pathifier	Bioconductor package	https://www.bioconductor.org/packages/release/bioc/html/pathifier.html
Nbclust	CRAN	https://cran.r-project.org/web/packages/NbClust/index.html
PRISM	Broad institute	https://depmap.org/repurposing
Python version	Python Software Foundation	https://www.python.org
SHAP	Python	https://shap.readthedocs.io/en/latest/