Skip to main content
. Author manuscript; available in PMC: 2024 Nov 15.
Published in final edited form as: Birth Defects Res. 2023 Apr 17;115(19):1785–1808. doi: 10.1002/bdr2.2178

Figure 3.

Figure 3.

The biogenesis and function of canonical miRNAs. The RNA Pol II or Pol III transcribes the miRNA gene to pri-miRNA, which then is processed by the microprocessor to form pre-miRNA. The pre-miRNA is exported to the cytoplasm by EXPORTIN5. In the cytoplasm, the pre-miRNA is cleaved by DICER to produce the miRNA duplex. The duplex is loaded onto AGO2. Only one strand will form the mature RISC with AGO2, and the other strand is ejected. The mature RISC will bind to target mRNA and silence gene expression by mRNA degradation or translational repression.