Table 1.
ncRNAs involved in pancreatic diseases
| ncRNA | Targets/Mechanism | Related phenotypes/diseases | Reference |
|---|---|---|---|
| LINC00261 | Recruit SMAD2/3 to Foxa2 promoter and promote Foxa2 expression | Κnockdown of LINC00261 decreases endoderm differentiation | (Gaertner et al., 2020; Jiang et al., 2015; Swarr et al., 2019) |
| DIGIT | Upregulate GSC in trans | Depletion of DIGIT inhibits endoderm differentiation | (Daneshvar et al., 2016) |
| PLUTO | Regulate the interaction of Pdx1 enhancer clusters and promoter | PLUTO is downregulated in patients with impaired glucose tolerance and T2D | (Akerman et al., 2017) |
| HI-LNC25 | Regulate GLIS3 | Knocking down HI-LNC25 decreased GLIS3, which contributes to diabetes | (Morán et al., 2012) |
| H19 | Form a complex with MBD1 and deposit repressive histone modifications on target genes | H19 regulates β-cell proliferation during postnatal development and insulin resistance | (Monnier et al., 2013; Sanchez‑Parra et al., 2018) |
| βlinc1 | Regulate the expression of endocrine genes in cis | Mice lacking βlinc1 show reduced β-cell number during embryo stages and develop glucose intolerance | (Arnes et al., 2016) |
| miR-26a | TET enzymes | MiR-26a overexpression promotes β-cell number | (Fu et al., 2013) |
| miR-29 | YY1, Dnmt3a, Dnmt3b | MiR-29 suppresses insulin secretion | (Wang et al. 2008; Fabbri et al. 2007; Garzon et al. 2009) |
| miR-9 | Sirt1, Baf53a | MiR-9 decreases insulin exocytosis | (Ramachandran et al. 2011; Yoo et al. 2011; Yoo et al. 2009; Abernathy et al. 2017; Saunders et al. 2010) |
| miR-124 | Baf53a | MiR-124 increases Ca2+ concentration in β-cells | (Yoo et al. 2011; Yoo et al. 2009; Abernathy et al. 2017) |
| miR-375 | Cadm1, Pdk1, Mtpn, Gephyrin, Ywhaz | Diabetes | (Poy et al. 2009; Kloosterman et al. 2007; Lahmy et al. 2014; Tattikota et al. 2014; Tattikota et al. 2013; Poy et al. 2004; El Ouaamari et al. 2008) |
| miR-7 | Snca, Cspa, Pfn2, Basp1, Pax6, Mapkap1, p70S6K, Mknk1/2, eIF4E | Diabetes | (Nieto et al. 2012; Latreille et al. 2014; Wang et al. 2013; Kredo-Russo et al. 2012) |
| miR-30 | Vimentin, Snail1, NeuroD1, Map4k4, Rfx6 | Diabetes | (Tang et al. 2009; Joglekar et al. 2009; Zhao et al. 2012; Kim et al. 2013; Liao et al. 2013) |
| miR-21 | Pdcd4 | Diabetes, pancreatitis, pancreatic cancer | (Dixit et al. 2016; Ruan et al. 2011; Assmann et al. 2017; Khan et al. 2015; Rachagani et al. 2015) |
| miR-24 | Men1, Sox6, Hnf1α, Neurod1, | Diabetes | (Vijayaraghavan et al. 2014; Zhu et al. 2013; Melkman-Zehavi et al. 2011) |