TABLE 1.

IC₅₀s for inhibition of DNA-modifying enzymes by polyhydroxylated aromatic inhibitors of integrase^a

Enzyme	IC50 (μM)
	QLZ	ATC	TMS	QTN	LCH	ELA	ARS
HIV-1 integrase	4	0.5	12	1	0.13	5	3
MoMLV RT (Mn)	0.11 ± 0.06	0.45 ± 0.3	>50	0.23 ± 0.15	0.58 ± 0.24	0.68 ± 0.45	0.14 ± 0.09
MoMLV RT (Mg)	2.9 ± 0.8	3.8 ± 1	>50	1.2 ± 0.9	8.3 ± 6.3	1.7 ± 1.9	0.75 ± 0.08
PvuII	15 ± 9	>50	>50	7 ± 6	>50	48 ± 22	22 ± 2
EcoRI	6 ± 4	>50	13 ± 2	2 ± 0.1	>50	2 ± 1	16 ± 1
MCV topoisomerase	>50	>50	>50	>50	>50	>50	>50
EcoRI methylase	>50	>50	>50	>50	>50	>50	>50
CpG methylase	>50	>50	>50	>50	>50	>50	>50

^aIC₅₀s for inhibition of integrase (terminal cleavage) are from this work unless indicated otherwise. Those for QLZ (28), ATC (23), QTN (34), and LCH (64) have been presented elsewhere. The IC₅₀ for integrase inhibition was determined in the presence of Mn²⁺.