Table 2.
Serum amino acids concentration in patients with CD according to disease activity.
| All | Active | Quiescent | Reference (35, 36) | |
|---|---|---|---|---|
| EAA, μM/L | ||||
| Valine | 233 (79) | 223.5 (84)* | 264 (76) | 187–411 |
| Leucine | 139 (57) | 127 (59.3)* | 146 (53) | 82–258 |
| Isoleucine | 74 (26) | 73.5 (26) | 74 (25) | 42–111 |
| Threonine | 146 (65) | 147.5 (64.3) | 145 (67) | 109–268 |
| Lysine | 176 (60) | 169.5 (51) | 183 (66) | 150–286 |
| Methionine | 28 (10) | 26.5 (10) | 29 (10) | 21–44 |
| Histidine | 88 (22) | 84 (24.8) | 90 (18) | 72–131 |
| Tryptophan | 6 (3) | 6 (3) | 7 (3) | 10–30 |
| Phenylalanine | 64 (17) | 60 (17.3) | 67 (14) | 59–112 |
| BCAA | 445 (149) | 421 (156) | 484 (154) | – |
| Total EAAs | 908 (264) | 862 (253) | 957 (263) | – |
| NEAA, μM/L | ||||
| Glutamic acid | 73 (45) | 85.5 (52.3)* | 67 (50) | 67–223 |
| Asparagine | 60 (15) | 59.9 (15.8) | 60 (16) | 43–87 |
| Arginine | 101 (34) | 95.5 (37) | 107 (28) | 36–172 |
| Aspartic acid | 23 (16) | 25 (15.8)* | 22 (14) | 24–102 |
| Glutamine | 664 (141) | 644 (187.5)** | 693 (42) | 432–871 |
| Serine | 147 (42) | 147.5 (37.3) | 146 (42) | 111–297 |
| Glycine | 287 (113) | 296.5 (139)* | 280 (98) | 240–460 |
| Tyrosine | 62 (20) | 61 (21.8) | 62 (17) | 45–107 |
| Alanine | 379 (132) | 376.5 (143.5) | 397 (129) | 193–597 |
| Cysteine | 31 (12) | 30.5 (12.5) | 31 (11) | 5–55 |
| Total NEAAs | 1864 (417) | 1853 (469) | 1890 (316) | – |
| Other metabolites, μM/L | ||||
| Ornithine | 93 (12) | 99.5 (46.8) | 91 (44) | 63–133 |
| Citrulline | 33 (11) | 33 (10.8) | 33 (14) | 15–57 |
| Taurine | 151 (70) | 150 (57) | 155 (78) | 50–270 |
Data are expressed as median and interquartile range. BCAA, branched-chain amino acid; EAAs, essential amino acids; NEAAs, non-essential amino acids. **p < 0.01; *p < 0.05.