TABLE 3.

The associations among three plasma proteins, CRP, C3, or CHF, at baseline and AD risk after stratified by APOE ε4 status in the FHS study.

	APOE ε4 non‐carriers			APOE ε4 carriers
Proteins	n	HR [95% CI]	P value	n	HR [95% CI]	P value
CRP	1261	1.17 [0.93, 1.46]	0.18	374	1.38 [1.02, 1.89]	0.039
C3	1261	0.93 [0.73, 1.19]	0.58	374	1.15 [0.85, 1.56]	0.37
CFH	1261	0.95 [0.74, 1.20]	0.64	374	1.41 [1.03, 1.94]	0.031

Note: The FHS Offspring (Gen 2) participants were divided into APOE ε4 non‐carriers and APOE ε4 carriers. We used Cox regression models in each APOE genotype group to examine the relationship among the three plasma inflammation proteins, CRP, C3, or CFH, and the incidence of AD after adjusting for sex, age, and education. Specifically, we used the z score of the log10‐transformed values of the protein levels as predictors. We reported the HRs with their 95% CIs. All statistical models were tested using a two‐sided hypothesis test with a significance level of P < 0.05.

Abbreviations: AD, Alzheimer's disease; APOE, apolipoprotein E; C3, complement C3; CFH, complement factor H; CI, confidence interval; CRP, C‐reactive protein; FHS, Framingham Heart Study; HR, hazard ratio.