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Inhibition profiles of CTX-M-4 wild-type and S237A mutant β-lactamases
| β-Lactamasea | IC50 (μM) of inhibitorb
|
||
|---|---|---|---|
| Clavulanate | Sulbactam | Tazobactam | |
| CTX-M-4 | 1.0 | 14 | 0.10 |
| S237A mutant | 2.5 | 17 | 0.12 |
Two hundred fifty units of β-lactamase was used.
IC50s were the mean values of three measurements not differing by more than 10%.
