TABLE 2.

Time-kill results

Drug and MIC level	No. of strains killed by the following times at the indicated Δlog10 of CFU/ml valuesa:
	3 h			6 h			12 h			24 h
	−1	−2	−3	−1	−2	−3	−1	−2	−3	−1	−2	−3
Grepafloxacin
8× MIC	8	3	0	12	4	2	12	12	10	12	12	12
4× MIC	4	1	0	11	2	0	12	11	10	12	12	12
2× MIC	3	0	0	10	4	0	12	11	8	12	11	10
MIC	0	0	0	3	0	0	8	7	0	7	6	5
0.5× MIC	0	0	0	1	0	0	1	1	0	2	2	2
Ciprofloxacin
8× MIC	8	3	0	12	10	4	12	12	9	12	12	12
4× MIC	8	2	0	12	8	3	12	12	9	12	12	12
2× MIC	7	2	0	12	7	3	12	11	7	12	12	11
MIC	2	0	0	7	3	1	10	9	4	10	10	5
0.5× MIC	0	0	0	0	0	0	2	0	0	2	0	0
Levofloxacin
8× MIC	10	4	1	12	12	5	12	12	10	12	12	12
4× MIC	9	4	1	12	9	4	12	12	10	12	12	12
2× MIC	9	4	0	12	8	1	12	12	10	12	12	12
MIC	3	2	0	8	1	1	8	8	4	8	7	6
0.5× MIC	0	0	0	0	0	0	0	0	0	1	1	1
Sparfloxacin
8× MIC	8	3	0	12	6	3	12	12	9	12	12	12
4× MIC	4	1	0	12	6	2	12	10	7	12	12	12
2× MIC	4	0	0	11	4	1	12	8	6	12	12	9
MIC	2	0	0	7	2	1	6	5	1	6	4	2
0.5× MIC	0	0	0	0	0	0	0	0	0	0	0	0
Amoxicillin-clavulanate
8× MIC	11	6	0	12	10	4	12	12	9	12	12	12
4× MIC	8	3	0	11	9	2	12	12	9	12	12	12
2× MIC	8	2	0	10	9	2	12	12	9	12	12	12
MIC	6	1	0	8	4	0	11	8	6	10	8	8
0.5× MIC	0	0	0	1	0	0	2	1	0	5	3	2
Clarithromycinb
8× MIC	5	2	0	8	3	2	7	6	5	8	8	8
4× MIC	4	1	0	7	3	2	7	6	5	8	8	8
2× MIC	4	1	0	6	3	2	7	6	5	8	8	8
MIC	3	1	0	4	3	0	7	6	3	8	8	7
0.5× MIC	0	0	0	4	1	0	3	3	3	5	4	2

^aΔlog₁₀ of CFU/ml values that were lower than those at 0 h. 

^bTime-kill studies were not performed for four strains for which the clarithromycin MICs were >64 μg/ml.