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. 2023 Aug 23;12(9):1896–1911. doi: 10.21037/tlcr-23-118

Figure 4.

Figure 4

Survival of Filipinos with EGFR-mutant NSCLC treated with different TKIs and correlation with PD-L1 expression. The Kaplan-Meier method was used to analyze the (A) median PFS and (B) median OS of Filipinos with EGFR-mutant NSCLC. The P values of the curves were determined using the log-rank test. ns, not significant. (C) Pearson’s correlation of EGFR-TKIs with EGFR mutations and PD-L1 expression. The heatmap score (range, −1 to 1) represents the Pearson’s coefficient. (D) Proteome network of proteins associated with signaling pathways involved in EGFR-TKI resistance and PD-L1 expression. The protein interaction network was analyzed using STRING interaction network. EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer; TKIs, tyrosine kinase inhibitors; PD-L1, programmed death-ligand 1; PFS, progression-free survival; OS, overall survival.