Table 6.

ToxRTool in vitro studies.

ToxRTool criteria:

1. Was the test substance identified?

2. Is the purity of the substance given?

3. Is information on the source/origin of the substance given?

4. Is all information on the nature and/or physico-chemical properties of the test item given, which you deem indispensable for judging the data?

5. Is the test system described?

6. Is information given on the source/origin of the test system?

7. Are necessary information on test system properties, and on conditions of cultivation and maintenance given?

8. Is the method of administration given?

9. Are doses administered or concentrations in application media given?

10. Are frequency and duration of exposure as well as time-points of observations explained?

11. Were negative controls included?

12. Were positive controls included?

13. Is the number of replicates (or complete repetitions of experiment) given?

14. Are the study endpoint(s) and their method(s) of determination clearly described?

15. Is the description of the study results for all endpoints investigated transparent and complete?

16. Are the statistical methods for data analysis given and applied in a transparent manner?

17. Is the study design chosen appropriate for obtaining the substance-specific data aimed at?

18. Are the quantitative study results reliable?