Table 1.
Characteristic and main findings of the included papers that show an association between ECM remodeling and tumor immune traits.
| Ref | Molecule | Tumor type | Year | Enrolled Patient | Queried Databases | Association with immune traits |
|---|---|---|---|---|---|---|
| (28) | ABI3BP | LUAD | 2023 | / | TIMER, GEPIA, TCGA, HPA (n=504) | correlation with B and CD4+ T memory cells, Tregs, B cells, T cells, CD4+ T, DC activation, and Ecs |
| (29) | ADAM12 | CRC | 2021 | / | Oncomine, UALCAN, TCGA, GEPIA, TIMER, TISIDB (n=86733) | correlation with CD4+ T, B, CD8+ T cells, neutrophils, macrophages, DC |
| (30) | ADAMs | PAAD | 2020 | / | TCGA (n=18313) | positive correlation with DC, B cells, neutrophils, CD8+ T cells, macrophages |
| (31) | BGN | TNBC | 2022 | / | TCGA, GEO (n=116) | negative correlation with CD8 + T cells |
| (32) | GC | 2022 | / | TCGA, GTEx (n=407) | positive correlation with NK cells and macrophages; negative correlation with Th17 cells | |
| (33) | COL10A1 | PAAD | 2022 | / | TCGA, GEO, GEPIA (n=182) | positive association with CD8+ T cells, M1 and M2 Mac; positive correlation with PD-L1, CTLA-4, CD73, HLA-E |
| (34) | COL5A1 | pan-cancer | 2022 | / | Oncomine, TCGA, CCLE, HPA, DNMIVD,cBioPortal | association with naive B cells, memory B cells, monocytes, macrophages, CD8+ and CD4+ T cells |
| (35) | COL6A1 | RCC | 2020 | 161 | / | association with PD-L1 expression |
| (36) | COL6A3 | PDAC | 2020 | / | TCGA, GEO (n=30) | association with CD4+ and CD8+ T, B cells, neutrophils, Mac and CD; association with CTLA-4, PD-1, PD-L1, PD-L2 |
| (37) | Collagen alignment | BC | 2021 | / | TCGA, GEO | negative correlation with anti-tumor T cells |
| (38) | Collagen I | BC | 2022 | 30 | TCGA, GEO (n=1161) | positive association with Th1 and Tregs, negative association with Th1 |
| (39) | Collagen I, III, V | NSCLC | 2021 | 120 | / | negative association of Coll I and III with Tregs and of Coll V with NK |
| (40) | Collagen, Elastin | BCC | 2022 | 22 | / | association with TILs counts |
| (41) | CTHRC1 | CRC | 2022 | / | TCGA, GEO (n=242) | correlation with TAMs, M2 macrophages, Tregs, T cell exhaustion, and MDSCs |
| (42) | GC | 2022 | / | TCGA, GEO, GSA (n=375) | correlation with M2 Mac, NK cells, Th1 cells and DC | |
| (43) | EMILIN2 | CRC | 2022 | 23 | TCGA (n=844) | negative association with M2 Mac; positive association with M1 Mac |
| (44) | LLG | 2021 | 97 | CGGA, TCGA (n=1018) | positive correlation with B cells, CD8+ T and CD4+ T cells, DC, Mac and neutrophils | |
| (45) | CCC | 2022 | / | TCGA, UCSC Xena (n=531) | positive correlation with CTLA-2, PD-1, LAG3, and TIGIT | |
| (46) | LOXL3 | HCC | 2021 | / | TCGA, TIMER, GTEx (n=52) | positive correlation with CD4+ T and CD8+ T cells, B cells, DC, neutrophils, Mac, B cells |
| (47) | LOXL4 | HCC | 2021 | 90 | / | association with PD-L1 expression |
| (48) | MMP1 | HCC | 2022 | / | TCGA, TIMER, GEO (n=11104) | association with activated DC, Mac, CD4+ T cells and MDSC |
| (49) | MMP9 | pan-cancer | 2022 | / | TCGA, GTEx (n=33) | positively correlates with T cells, macrophages, Th1 cells, and T cell exhaustion |
| (50) | PCOLCE | BC | 2021 | / | METABRIC (n=273) | association with PD-1/PD-L1 expression level |
| (51) | pan-cancer | 2022 | / | TCGA, CPTAC, GEO (n=33) | positive correlation with CD4+ and CD8+ memory cells, CD4+ T, CD8+ T, NK cells | |
| (52) | PLOD2 | pan-cancer | 2022 | / | GTEx, CCLE (n=21) | negative correlation with memory B cells, activated NK cells, CD8+ T cells,Treg; positive correlation with Mac |
| (53) | SPP1 | LUAD | 2021 | / | TCGA, CPTAC (n=551) | correlation with low CD8+ Tcell infiltration and high M2-type macrophages |
| (54) | TNC | BC | 2020 | 160 | / | negative correlation with LC3B and CD8+ T cells |
| (55) | BC | 2021 | 219 | GEO | negative association with macrophages and CD8+ T cells | |
| (56) | OSCC | 2020 | 68 | GEO | positive correlation with CD11+ cells and Tregs | |
| (57) | LGG | 2022 | 62 | / | positive association with MDSC; negative association with effector T cells | |
| (58) | Versican | NSCLC | 2022 | / | GEO | positive association with DC, negative correlation with CD8+ T cells |
| (59) | MPM | 2022 | / | TGCA (n=12) | association with PD-1 overexpression and downregulation of CD127 | |
| (60) | CCa | 2010 | 149 | / | negative association with CD8+ T cells | |
| (61) | MM | 2016 | 19 | / | negative association with CD8+ T cells | |
| (62) | CRC | 2017 | 122 | / | negative association with CD8+ T cells |
BC, breast cancer; MM, myeloma; CCa, cervical cancer; MPM, pleural mesothelioma; CCC, clear cell carcinoma; CRC, colorectal cancer; NSCLC, non-small cell lung cancer; LGG, low grade glioma; OSCC, oral squamous cell carcinoma; LUAD, lung adenocarcinoma; HCC, hepatocellular carcinoma; PDAC, pancreatic ductal adenocarcinoma; PAAD, pancreatic adenocarcinoma.