Extended Data Fig. 5 |. micro-CT images of the lungs of SARS-CoV-2-infected Syrian hamsters, related to Figure 3e.
a-b, Syrian hamsters were intranasally inoculated with PBS (mock) (a), or with 103 PFU of Omicron/BA.1 (NC928), Omicron/BA.2 (NCD1288) or Omicron/BA.2 (HP353) (b). In addition to the images shown in Fig. 3e, the remaining representative Micro-CT images of the lungs of mock-infected hamsters (n = 2) and virus-infected hamsters (n = 3) at 7 dpi are shown. c, Representative micro-CT axial and coronal images of the lungs of four hamsters per group inoculated with 105 PFU of Omicron/BA.1 (NC928) or 105 PFU of Omicron/BA.2 (NCD1288) at 7 dpi. Lung abnormalities included minimal, patchy, ill-defined, peri-bronchial ground glass opacity (white arrowheads), and few, small, focal rounded/nodular regions (black arrows), consistent with minimal pneumonia. Coronal CT images were reformatted to optimize lesion visualization. CT severity scores for hamsters inoculated with 105 PFU of Omicron/BA.1 (n = 4) or Omicron/BA.2 (n = 4) were analyzed by using the unpaired student’s t-test. Vertical bars show the mean ± s.e.m. Points indicate data from individual hamsters. Data are from one experiment.