Table 1.
Age, gender, and biochemical differences between patients with PHP and HPT and controls. Measurements are expressed as median [Interquartile Range (IQR)].
| Normal range | PHP n = 60 |
HPT n = 60 |
Controls n = 120 |
p-value | |
|---|---|---|---|---|---|
| Age | |||||
| (years) | - | 38.9 (30.2–44.8) | 41.0 (28.7–47.3) | 0.454 | |
| 35.1 (27.5–41.1)*° | 42.4 (34.9–46.4) | 0.010 | |||
| Sex | |||||
| Females (%) | - | 72 (60.0) | 66 (55.0) | 0.514 | |
| 31 (51.7) | 41 (68.3) | ||||
| Males (%) | - | 48 (40.0) | 54 (45.0) | ||
| 29 (48.3) | 19 (38.7) | ||||
| Biochemical parameters | |||||
| Serum Ca (mmol/L) | 2.12–2.63 | 1.89 (1.56–2.20) # | 2.05 (1.96–2.18)^ | 2.38 (2.30–2.43) | <0.0001 |
| Serum P (mmol/L) | 0.81–1.65 | 1.37 (1.20–1.83) # | 1.37 (1.20–1.51)^ | 1.16 (1.00–1.31) | <0.0001 |
| Ca/P | – | 1.40 (0.84–1.81) # | 1.52 (1.29–1.76)^ | 2.04 (1.81–2.30) | <0.0001 |
| Serum PTH (ng/L) | 15–88 | 264 (125–425) # § | 10.1 (5.3–15.0)^ | 31.6 (23.0–41.7) | <0.0001 |
| Ca/P × PTH (ng/L) | – | 285.4 (176.7–477.8) # § | 18.3 (6.8–25.2)^ | 63.8 (44.5–87.4) | <0.0001 |
| Serum creatinine (µmol/L) | 44.2–106.1 | 79.6 (61.9–88.4) | 73.4 (59.2–84.0) | 70.7 (61.9–79.6) | 0.208 |
| Serum albumin (g/L)** | 35–50 | 43 (38–46) | 41 (40–43)^ | 44 (41–46) | <0.0001 |
| Serum-corrected Ca (mmol/L)** | – | 1.90 (1.55–2.14) # | 2.05 (1.95–2.14)^ | 2.30 (2.23–2.35) | <0.0001 |
| Corrected Ca/P Ratio** | – | 1.51 (1.10–1.84) # | 1.49 (1.28–1.70)^ | 2.00 (1.75–2.23) | <0.0001 |
PHP, pseudohypoparathyroidism; HypoPT, hypoparathyroidism; Ca, serum calcium; P, serum phosphorus; Ca/P, serum calcium–to–phosphorus ratio; **available in 41 patients with PHP (68.3%), 58 patients with HypoP (96.7%), and 98 controls (81.7%). * PHP vs. controls, p = 0.021; ° PHP vs. HypoPT, p = 0.003; # PHP vs. controls, p < 0.0001; ^ HypoPT vs. controls, p < 0.0001; and § PHP vs. HypoPT, p < 0.0001. P-values reaching significance (<0.05) are reported in bold.