Table 2.
Comparison of biochemical parameters between patients with PHP1A and PHP1B. Measurements are expressed as median (IQR).
| Normal range | PHP1A n = 14 |
PHP1B n = 43 |
p-value | |
|---|---|---|---|---|
| Age (years) | 38.6 (33.8–43.2) | 34.0 (27.3–41.1) | 0.182 | |
| Sex | ||||
| Females (%) | - | 6 (42.9) | 22 (51.2) | 0.589 |
| Males (%) | - | 8 (57.1) | 21 (48.8) | |
| Biochemical parameters | ||||
| Serum Ca (mmol/L) | 2.12–2.63 | 2.20 (1.97–2.30) | 1.75 (1.50–1.98) | <0.0001 |
| Serum P (mmol/L) | 0.81–1.65 | 1.26 (1.12–1.43) | 1.51 (1.20–1.91) | 0.069 |
| Ca/P | – | 1.81 (1.43–2.05) | 1.24 (0.83–1.66) | 0.003 |
| Serum PTH (ng/L) | 15–88 | 111 (62–291) | 308 (205–454) | 0.004 |
| Ca/P × PTH (ng/L) | – | 173.9 (111.6–570.7) | 360.0 (242.5–477.8) | 0.171 |
| Serum creatinine (µmol/L) | 44.2–106.1 | 70.7 (61.9–83.1) | 84.0 (59.2–94.6) | 0.559 |
PHP1A,pseudohypoparathyroidism type 1A; PHP1B, pseudohypoparathyroidism type 1B; Ca, serum calcium; P, serum phosphorus; Ca/P, serum calcium–to–phosphorus ratio (Ca and P measured in mmol/L); PTH, serum parathyroid hormone. P-values reaching significance (<0.05) are reported in bold.