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. 2023 Oct 3;13:1259822. doi: 10.3389/fcimb.2023.1259822

Figure 4.

Figure 4

TLR agonists do not affect -induced leukocyte recruitment into the lungs at 12 day after i.n. MVA-SARS-2-S administration. (A, B) Spectral flow cytometry analysis of the cellular composition of lung (A) and broncho-alveolar lavage (BAL) (B) depicted as UMAP plots of concatenated samples of two representative mice from each experimental group. Alv. Mfg – alveolar macrophages; Int. Mfg – interstitial macrophages. (C, D) Absolute cell numbers of T cells, B cells, monocytes, and alveolar macrophages in lung (C) and BAL (D). Pooled data from four independent experiments with n = 8 mice per group. Individual values (symbols) and mean group value (lines). Statistical analysis was done on log-transformed using Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Black stars - difference to control group; Orange stars – difference between groups receiving vaccine and vaccine mixed with TLR agonists, as denoted by the line.