Cameron 1991.

Methods	Randomised controlled trial conducted in the UK
Participants	30 people with venous leg ulcers: Group 1: 15 Group 2: 15 Mean baseline ulcer area (cm2—variability data not reported): Group 1: 17.3. Group 2: 16.3 Mean (range) baseline ulcer duration: Group 1: 6 years (1 month to 36 years); Group 2: 2.7 years (6 months to 9 years) 5 participants in each group had Gram‐positive bacteria present in their wounds at baseline. There was no report of signs and symptoms of clinical infection.
Interventions	1. White soft paraffin tulle gras and compression therapy 2. Mupirocin‐impregnated tulle gras and compression therapy
Outcomes	After 12 weeks complete healing: 1. 46% 2. 53% Mean percentage change in ulcer area: 1. 68% 2. 50% Eradication of Gram‐positive bacteria 1. 0/5 2. 5/5
Notes	No withdrawals reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "patients were randomised into 2 treatment groups" Comment: It was not stated how the sequence was generated
Allocation concealment (selection bias)	Unclear risk	Quote: "patients were randomised into 2 treatment groups" Comment: allocation concealment was not mentioned
Blinding (performance bias and detection bias) Participant blinded to the intervention	Low risk	Quote: "The study was a randomised double‐blind placebo controlled pilot study"
Blinding (performance bias and detection bias) Outcome assessor blinded to the intervention	Unclear risk	Quote: "The study was a randomised double blind placebo controlled pilot study" Comment: It was not stated that outcome assessors were blinded
Incomplete outcome data (attrition bias) Drop out rate described	Unclear risk	30 patients were recruited; no withdrawals were reported
Incomplete outcome data (attrition bias) Drop out rate acceptable	Unclear risk	Withdrawal rate was not described
Incomplete outcome data (attrition bias) ITT analysis	Unclear risk	Method of analysis not described
Baseline factors comparable	High risk	The ulcers in Group 1 had longer mean duration than those in Group 2 (2.7 years versus 6 years)