Summary of findings 3. Different dosing regimens of aminoglycosides (daily versus 8 hourly) for acute pyelonephritis in children.
| Different dosing regimens of aminoglycosides (daily versus 8 hourly) for acute pyelonephritis in children | ||||||
| Patient or population: children with acute pyelonephritis Intervention: different dosing regimens of aminoglycosides (daily versus 8 hourly) | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Daily dose | 8 hourly dose | |||||
| Persistent bacteriuria after 1 to 3 days of treatment | Study population | RR 1.05 (0.15 to 7.27) | 435 (3) | ⊕⊕⊝⊝ low1,2 | ||
| 9 per 1000 | 10 per 1000 (1 to 67) | |||||
| Moderate | ||||||
| 0 per 1000 | 0 per 1000 (0 to 0) | |||||
| Hearing impairment following treatment | Study population | RR 2.83 (0.33 to 24.56) | 271 (3) | ⊕⊕⊝⊝ low1,2 | ||
| 0 per 1000 | 0 per 1000 (0 to 0) | |||||
| Moderate | ||||||
| 0 per 1000 | 0 per 1000 (0 to 0) | |||||
| Increase in serum creatinine during treatment | Study population | RR 0.75 (0.2 to 2.82) | 419 (3) | ⊕⊕⊝⊝ low1,2 | ||
| 25 per 1000 | 19 per 1000 (5 to 70) | |||||
| Moderate | ||||||
| 25 per 1000 | 19 per 1000 (5 to 70) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Unclear allocation concealment in two of three studies 2 Few events resulting in wide confidence intervals