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. 2023 Oct 17;13(43):30462–30490. doi: 10.1039/d3ra05953g

s-Triazine-based molecular hybrids as antibacterial agent.

Compounds Most potent compound MIC/ZOI of ref. drug Refs.
Substituents MIC/zone of inhibition
graphic file with name d3ra05953g-u35.jpg graphic file with name d3ra05953g-u36.jpg MIC (μM) S. aureus: LATCC 33591 = 3.9, MRSA BRS3 = 0.95, MRSA C1 = 1.95, MRSA C7 = 3.9, MRSA C14 = 3.9, MRSA G1 = 7.8 MIC (μM), AMK (Amikacin) S. aureus: ATCC 33591= 31.3, MRSA BRS3= 15.6, MRSA C1 = 3.9, MRSA C7 = 7.8, MRSA C14 = 7.8, MRSA G1 = 15.6 66
graphic file with name d3ra05953g-u37.jpg graphic file with name d3ra05953g-u38.jpg Zone of inhibition in (mm), Gram positive: S. aureus = 14.84 ± 0.3, S. faecalis = 14.84 ± 0.4, B. substilis = 14.4 ± 0.3, P. vulgaris = 15.64 ± 0.8, B. pumilus = 16.64 ± 0.4, Gram negative: E. coli = 14.04 ± 0.44, K. penumoniae = 11.04 ± 0.43 Zone of inhibition in (mm), Norfloxacin Gram positive:S. aureus = 17.44 ± 0.3, S. faecalis = 17.45 ± 0.5, B. substilis = 16.64 ± 0.3, P. vulgaris = 17.64 ± 0.4, B. pumilus = 18.45 ± 0.4, Ciprofloxacin Gram negative: E. coli = 17.45 ± 0.36, K. penumoniae = 17.64 ± 0.65 67
graphic file with name d3ra05953g-u39.jpg graphic file with name d3ra05953g-u40.jpg (MIC) μg mL−1: E. coli = 256, S. aureus = 256 (MIC) μg mL−1 Chloramphenicol: E. coli = 128, S. aureus = 256 68
graphic file with name d3ra05953g-u41.jpg ZOI: 60a: E. coli = 30 ± 0.42 mm, B. subtillis = 28 ± 0.22 mm, S. phyogenes = 19 ± 0.56 mm, P. aregeunosa, 60b: E. coli = 35 ± 0.12 mm, B. subtillis = 18 ± 0.32 mm, S. phyogenes = 20 ± 0.56 mm ZOI: Sulfadiazine: E. coli = 26 ± 0.83 mm, B. subtillis = —, Streptomycin, S. phyogenes = 10 ± 0.66 mm 69
graphic file with name d3ra05953g-u42.jpg graphic file with name d3ra05953g-u43.jpg MIC (μg μL−1): E. coli = 1.25, S. enteritidis = 1.25, S. aureus = 1.25, B. subtilis = 1.25 MIC (μg μL−1): Penicillin, E. coli = 6, S. enteritidis = 6, S. aureus = 1.5, B. subtilis = 1.5 70
graphic file with name d3ra05953g-u44.jpg graphic file with name d3ra05953g-u45.jpg MIC (mg L−1): S. aureus = 3.90, E. faecalis = 62.5, E. coli = 62.5, P. aeruginosa = 250, IC50 [mg L−1] = 2.4 71
graphic file with name d3ra05953g-u46.jpg graphic file with name d3ra05953g-u47.jpg MIC (μg mL−1): S. aureus = 6.25, P. aeruginosa = 12.5, B. cereus = 100, K. pneumoniae = 100 MIC (μg mL−1): Ciprofloxacin: S. aureus = 3.125, P. aeruginosa = 3.125, B. cereus = 3.125, K. pneumoniae = 3.125 72
graphic file with name d3ra05953g-u48.jpg graphic file with name d3ra05953g-u49.jpg MIC (μM): 64b-1: DS = 2.49, MDR = 9.91, XDR = 39.72, 64b-2: DS = 2.28, MDR = 18.14, XDR = 36.31, IC50 (μM) for InhA: 64b-1: 3.90 ± 0.09, 64b-2: 2.47 ± 0.11 MIC (μM): Isoniazid: DS = 0.88, MDR = Resistant, XDR = resistant, IC50 (μM) for InhA: triclosan = 1.22 ± 0.13 73
graphic file with name d3ra05953g-u50.jpg R = –CF3 MIC (μg mL−1): Staphylococcus aureus = 25, Bacillus subtilis = 62.5, Clostridium tetani = 100, Salmonella typhi = 100, Escherichia coli = 12.5, Vibrio cholerae = 250 Norfloxacin MIC (μg mL−1): Staphylococcus aureus = 100, Bacillus subtilis = 10, Clostridium tetani = 50, Salmonella typhi = 10, Escherichia coli = 10, Vibrio cholerae = 10 74