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. 2023 Oct 17;13(43):30462–30490. doi: 10.1039/d3ra05953g

s-Triazine-based molecular hybrids as antioxidants and anti-Alzheimer agents.

Compounds Most potent compound IC50 ref. drug Refs.
Substituents IC50
graphic file with name d3ra05953g-u77.jpg graphic file with name d3ra05953g-u78.jpg IC50 = 9.54 μg mL−1 96
graphic file with name d3ra05953g-u79.jpg graphic file with name d3ra05953g-u80.jpg IC50 (μM) 80a: 3D7 = 13.25 ± 0.82, Dd2 = 16.30 ± 0.93, 80b: 3D7 = 88.74 ± 2.14, Dd2 = 14.72 ± 0.82 Chloroquine: 3D7 = 2.18 ± 0.12, Dd2 = 3.70 ± 0.13 97
graphic file with name d3ra05953g-u81.jpg graphic file with name d3ra05953g-u82.jpg Dead rings trophozoites IC50 (μg mL−1) = 53.85 ± 0.42, Vero cells: CC50 (μg mL−1) = 550.26, SI index = 10.21 Chloroquine: Dead rings trophozoites: IC50 (μg mL−1) = 0.7 ± 0.004, Vero cells: CC50 (μg mL−1) = 560.29, SI index = 801.28 98
graphic file with name d3ra05953g-u83.jpg graphic file with name d3ra05953g-u84.jpg IC50 (obs.) = 1.36, log IC50 (obs.) = 0.134 99