s-Triazine-based molecular hybrids as antioxidants and anti-Alzheimer agents.
| Compounds | Most potent compound | IC50 ref. drug | Refs. | |
|---|---|---|---|---|
| Substituents | IC50 | |||
|
|
IC50 = 9.54 μg mL−1 | — | 96 |
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|
IC50 (μM) 80a: 3D7 = 13.25 ± 0.82, Dd2 = 16.30 ± 0.93, 80b: 3D7 = 88.74 ± 2.14, Dd2 = 14.72 ± 0.82 | Chloroquine: 3D7 = 2.18 ± 0.12, Dd2 = 3.70 ± 0.13 | 97 |
|
|
Dead rings trophozoites IC50 (μg mL−1) = 53.85 ± 0.42, Vero cells: CC50 (μg mL−1) = 550.26, SI index = 10.21 | Chloroquine: Dead rings trophozoites: IC50 (μg mL−1) = 0.7 ± 0.004, Vero cells: CC50 (μg mL−1) = 560.29, SI index = 801.28 | 98 |
|
|
IC50 (obs.) = 1.36, log IC50 (obs.) = 0.134 | — | 99 |